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Biological activities of four essential oils against Anopheles gambiaein Burkina Faso and their in vitroinhibition of acetylcholinesterase

Dimitri Wendgida WANGRAWA1,2, Athanase BADOLO1,2*, Wamdaogo Moussa GUELBÉOGO2, Martin KIENDRÉBEOGO3, Roger Charles Honorat NÉBIÉ4, N’Falé SAGNON2 and Antoine SANON1

1Laboratoire d’Entomologie Fondamentale et appliquée, Université de Ouagadougou, BP 7021 Ouagadougou 03, Burkina Faso.
2Centre National de Recherche et de Formation sur le Paludisme, BP 2208 Ouagadougou 01, Burkina Faso.
3LABIOCA, Université de Ouagadougou, BP 7021 Ouagadougou 03, Burkina Faso.
4Centre National de Recherche Scientifique et Technologique, Burkina Faso.
*Corresponding author; E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; Tel +226 32469596; Fax +226 50305220

ABSTRACT

The control of malaria is still a challenge partly due to mosquito’s resistance to current available insecticides. The aim of this work was to evaluate the ovicidal, larvicidal and repellent activities of Lantana camara, Hyptis suaveolens, Hyptis spicigera and Ocimum canum essential oils against Anopheles gambiae s.l. according to the World Health Organization standard method. The in vitro acetylcholinesterase inhibition activity of these oils was also evaluated. The repellent effect using the method of “separated arms” was evaluated. Lantana camara oil was more effective on both eggs and larvae. The LD50 and LD90 values observed in this oil solution were respectively 53.59 and 170.89 ppm on eggs whereas LD50 and LD90 were 61 and 125 ppm respectively on larvae. All oils exhibited repellent activities against adult mosquitoes. The most effective repellent was the oil of Hyptis suaveolens with a 50% efficacy dose value of 67 ppm. The highest acetylcholinesterase inhibitory activity was observed with O. canum and H. suaveolens essential oils which IC50 was 0.21 and 0.55 µg/ml respectively. Results suggest that these essential oils have a potential for vector control and can be considered as a source of natural and ecofriendly substances for malaria vector control.

Keywords: Anopheles gambiae s.l., malaria, essential oil, acetylcholinesterase, insecticidal activity.

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