Bioactive compounds in the stem bark of Albizia coriaria (Welw. ex Oliver)

Robert BYAMUKAMA1*, Ganza BARBARA2, Jane NAMUKOBE1, Matthias HEYDENREICH3 and Bernard T. KIREMIRE1

1Department of Chemistry, College of Natural Sciences, Makerere University, P.O. Box 7062, Kampala, Uganda.
2Chemistry Department, Faculty of Science, Kyambogo University, P.O. Box 1, Kyambogo, Uganda.
3Institut für Chemie, Universität Potsdam, P.O. Box 60 15 53, D-14415 Potsdam, Germany.
* Corresponding author, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , Tel.: +256-701-548558


Albizia coriaria was investigated for the bioactive compounds present in its stem bark. The plant was selected on the basis of its widespread use in traditional herbal medicine. Extraction of the plant material was done with ethyl acetate, methanol and water and the bioactivity of each extract was tested against Pseudomonas aeruginosa and Escherichia coli. Separation and purification of the compounds in the most active (ethyl acetate) extract was done using a combination of chromatographic techniques. The compounds were identified by 1D and 2D -1H and 13C NMR techniques as well as Mass spectrometry (MS). Six compounds, namely: Lupeol (1), Lupenone (2), Betulinic acid (3), Acacic acid lactone (4), (+) – Catechin (5) and Benzyl alcohol (6) were identified and characterized from the ethyl acetate extract. The results of the bioactivity tests carried out in this study indicated that A. coriaria has potential antimicrobial activity. Four of the characterized compounds (1, 2, 3 & 5) have a wide range of biological activity reported in literature. This justifies the use of this plant in traditional medicine and indicates a promising potential for the development of medicinal agents from A. coriaria stem bark.

Keywords: Biological activity, Lupeol, Lupenone, Betulinic acid, Acacic acid lactone, (+) – Catechin.

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